1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide

Base Information

• Chemical Name: 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide
• CAS No.: 320575-21-1
• Molecular Formula: C₂₅H₂₄O₆S
• Molecular Weight: 452.528

Synonyms:1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide

Chemical Property of 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide

Chemical Property:

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Technology Process of 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide

There total 3 articles about 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-lithio-3,4,5-trimethoxybenzene (81952-68-3) + 2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide (182133-00-2) → 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide (320575-21-1)

Guidance literature:

1-lithio-3,4,5-trimethoxybenzene; With copper(l) iodide; In diethyl ether; at -23 ℃; for 1h;

2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide; In diethyl ether; at -23 - 20 ℃; for 12h; Further stages.;

DOI:10.1021/jo0004761

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide (320575-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / Br₂ / CHCl₃ / 0.5 h / 20 °C

2.1: 75 percent / aq. H₂O₂; TFA / CH₂Cl₂ / 2 h / 20 °C

3.1: CuI / diethyl ether / 1 h / -23 °C

3.2: 0.50 g / diethyl ether / 12 h / -23 - 20 °C

With copper(l) iodide; dihydrogen peroxide; bromine; trifluoroacetic acid; In diethyl ether; dichloromethane; chloroform;

DOI:10.1021/jo0004761

Reference yield:

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → 1,2-bis(4'-methoxyphenyl)-2'-(3'',4'',5''-trimethoxyphenylthioether)ethyne S-oxide (320575-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 75 percent / aq. H₂O₂; TFA / CH₂Cl₂ / 2 h / 20 °C

2.1: CuI / diethyl ether / 1 h / -23 °C

2.2: 0.50 g / diethyl ether / 12 h / -23 - 20 °C

With copper(l) iodide; dihydrogen peroxide; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1021/jo0004761

upstream raw materials:

1-lithio-3,4,5-trimethoxybenzene

2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

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