4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

Base Information

Chemical Name:4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole
CAS No.:1567402-54-3
Molecular Formula:C₂₄H₂₃ClN₄O₅S
Molecular Weight:514.989
Hs Code.:

Synonyms:4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

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Chemical Property of 4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

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Technology Process of 4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

There total 5 articles about 4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 80466-79-1
isoxazole-4-sulfonyl chloride

: 1567402-85-0
3-(azetidin-3-yloxy)-5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazole hydrochloride

: 1567402-54-3
4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 1567402-46-3
tert-butyl 3-((5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl)oxy)azetidine-1-carboxylate

: 1567402-54-3
4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

2: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 18312-46-4
(2-methoxyphenyl)hydrazine

: 1567402-54-3
4-[(3-{[5-(4-chlorophenyl)-1-(2-methoxyphenyl)-1H-pyrazol-3-yl]oxy}azetidin-1-yl)sulfonyl]-3,5-dimethylisoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 1 h / 20 °C

2: phosphorus trichloride / 1,2-dichloro-ethane / 2 h / 50 °C

3: caesium carbonate / N,N-dimethyl-formamide / 24 h / 70 - 80 °C

4: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

5: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; caesium carbonate; triethylamine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;