1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

Base Information

Chemical Name:1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine
CAS No.:1256466-67-7
Molecular Formula:C₄₅H₅₁N₄O₈PTe
Molecular Weight:934.496
Hs Code.:

1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

Synonyms:1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

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Chemical Property of 1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

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Technology Process of 1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

There total 5 articles about 1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1256466-66-6
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-phenyltellurouridine

: 132133-40-5
chloro-(2-cyanoethyl)-diisopropylaminophosphane

: 1256466-67-7
1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1093/nar/gkq1288

Reference yield:

: 1256466-66-6
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-phenyltellurouridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

: 1256466-67-7
1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 1256466-67-7
1-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphoramidite-5'-O-(4,4-dimethoxytrityl)-β-D-erythro-ribofuranosyl]-5-phenyltellurouridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 0.67 h / -78 °C

2.3: 1 h / -78 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1093/nar/gkq1288