D-3-deoxy-fluoro-phosphatidylinositol

Base Information

Chemical Name:D-3-deoxy-fluoro-phosphatidylinositol
CAS No.:143446-81-5
Molecular Formula:C₄₁H₇₈FO₁₂P
Molecular Weight:813.035
Hs Code.:

Synonyms:D-3-deoxy-fluoro-phosphatidylinositol

Suppliers and Price of D-3-deoxy-fluoro-phosphatidylinositol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-3-deoxy-fluoro-phosphatidylinositol

Chemical Property:

Purity/Quality:

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Technology Process of D-3-deoxy-fluoro-phosphatidylinositol

There total 13 articles about D-3-deoxy-fluoro-phosphatidylinositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 143446-80-4
D-2,4,5,6-Tetra-O-benzyl-3-deoxy-3-fluoro-myo-inositol 1-

: 143446-81-5
D-3-deoxy-fluoro-phosphatidylinositol

Guidance literature:: With hydrogen; palladium dihydroxide; In tert-butyl alcohol; for 23.5h; under 3750.3 Torr; Ambient temperature;
DOI:10.1021/jo00084a010

Reference yield:

: 30334-71-5
1,2-dipalmitoyl-sn-glycerol

: 143446-81-5
D-3-deoxy-fluoro-phosphatidylinositol

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / tetrazole / CH₂Cl₂; acetonitrile / 1.) r.t., 5 h, 2.) 35 - 40 deg C, 64 h

2: 98 percent / t-BuOOH / CH₂Cl₂ / 1.) ice bath, 90 min, 2.) r.t., 20 min

3: 89 percent / H₂ / 20percent Pd(OH)2/C / 2-methyl-propan-2-ol / 23.5 h / 3750.3 Torr / Ambient temperature

With 1H-tetrazole; tert.-butylhydroperoxide; hydrogen; palladium dihydroxide; In dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00084a010

Reference yield:

: 120444-24-8
D-3-deoxy-3-fluoro-myo-inositol

: 143446-81-5
D-3-deoxy-fluoro-phosphatidylinositol

Guidance literature:: Multi-step reaction with 10 steps

1: 2.) acetyl chloride / 1.) camphorsulfonic acid / 1.) DMF, 80 deg C, 4 h, 2.) CH₂Cl₂, MeOH, 23 deg C, 1 h

2: 96 percent / NaH / dimethylformamide / 1.) ice bath temp., 3 h, 2.) 8-10 deg C, then r.t., 3 h

3: 100 percent / aq. conc. HCl / methanol / 21 h / Ambient temperature

4: 1.) di-n-butyltin oxide / 1.) MeOH, reflux, 2 h, 2.) DMF, toluene, ice bath, 1 h

5: 98 percent / NaH / dimethylformamide / 5 h / Ambient temperature

6: 94 percent / aq. HCl / methanol / 5 h / Heating

7: 97 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 20 h / Ambient temperature

8: 79 percent / tetrazole / CH₂Cl₂; acetonitrile / 1.) r.t., 5 h, 2.) 35 - 40 deg C, 64 h

9: 98 percent / t-BuOOH / CH₂Cl₂ / 1.) ice bath, 90 min, 2.) r.t., 20 min

10: 89 percent / H₂ / 20percent Pd(OH)2/C / 2-methyl-propan-2-ol / 23.5 h / 3750.3 Torr / Ambient temperature

With 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; N,N-diisopropylamine tetrazolide; hydrogen; sodium hydride; di(n-butyl)tin oxide; acetyl chloride; hydrogenchloride; palladium dihydroxide; camphor-10-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00084a010