but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Base Information

Chemical Name:but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide
CAS No.:881653-73-2
Molecular Formula:C₂₅H₃₂N₂O₃Si
Molecular Weight:436.626
Hs Code.:

but-2-ynedioic acid benzyl-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Synonyms:but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

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Chemical Property of but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Chemical Property:

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Technology Process of but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

There total 4 articles about but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: dimethylcarbamoyl-propynoic acid

: 881653-57-2
N-benzyl-2-((tert-butyldimethylsilyl)oxy)aniline

: 881653-73-2
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -60 - -5 ℃;
DOI:10.1021/jo052335a

Reference yield:

: 2682-34-0
N,N-dimethylpropynamide

: 881653-73-2
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 3.40 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo052335a

Reference yield:

: 1624-53-9,3230-45-3,137838-23-4
2-(benzylideneamino)phenol

: 881653-73-2
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium borohydride / methanol / 0 °C

2: imidazole / CH₂Cl₂

3: 3.40 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

With 1H-imidazole; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1021/jo052335a