methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

Base Information

Chemical Name:methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate
CAS No.:232953-66-1
Molecular Formula:C₁₆H₂₀BrNO₄
Molecular Weight:370.243
Hs Code.:

Synonyms:methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

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Chemical Property of methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

Chemical Property:

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Technology Process of methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

There total 9 articles about methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1796-27-6
piperidine-1-carboxylic acid methyl ester

: 232953-66-1
methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / Et₄NBF₄ / Electrochemical reaction

2.1: TiCl₄; DIPEA / CH₂Cl₂ / cooling

2.2: CH₂Cl₂ / 20 °C

3.1: LiOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

4.1: diethyl ether / 20 °C

With lithium hydroxide; dihydrogen peroxide; titanium tetrachloride; N,N,N,N-tetraethylammonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol9905046

Reference yield:

: 56475-86-6
2-methoxy-piperidine-1-carboxylic acid methyl ester

: 232953-66-1
methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: TiCl₄; DIPEA / CH₂Cl₂ / cooling

1.2: CH₂Cl₂ / 20 °C

2.1: LiOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

3.1: diethyl ether / 20 °C

With lithium hydroxide; dihydrogen peroxide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol9905046

Reference yield:

: 2-[1-(4-bromo-phenyl)-2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethyl]-piperidine-1-carboxylic acid methyl ester

: 232953-66-1
methyl (2R,2'R)-2-(p-bromophenyl)-2-(N-methoxycarbonyl-2'-piperidyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

2: diethyl ether / 20 °C

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol9905046