4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

Base Information

Chemical Name:4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide
CAS No.:573949-85-6
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

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Technology Process of 4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

There total 6 articles about 4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110-91-8,99108-56-2
morpholine

: 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoyl chloride

: 573949-85-6
4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: With triethylamine; In 1,4-dioxane; for 5h; Reflux;
DOI:10.1134/S1070363215050096

Reference yield:

: 4035-86-3
4-(4-methoxyphenyl)tetrahydro-2-pyran-4-carbonyl chloride

: 573949-85-6
4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / toluene / 4 h / Reflux

2: sodium hydroxide / methanol; water / 2 h / Reflux

3: thionyl chloride / toluene / 12 h / Reflux

4: triethylamine / 1,4-dioxane / 5 h / Reflux

With thionyl chloride; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; toluene;
DOI:10.1134/S1070363215050096

Reference yield:

: 3648-78-0
4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile

: 573949-85-6
4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / ethylene glycol / 10 h / Reflux

2: thionyl chloride / benzene / 6 h / Reflux

3: triethylamine / toluene / 4 h / Reflux

4: sodium hydroxide / methanol; water / 2 h / Reflux

5: thionyl chloride / toluene / 12 h / Reflux

6: triethylamine / 1,4-dioxane / 5 h / Reflux

With thionyl chloride; triethylamine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; water; ethylene glycol; toluene; benzene;
DOI:10.1134/S1070363215050096