4035-86-3Relevant academic research and scientific papers
Synthesis and Antibacterial Activity of Novel (4-Methoxyphenyl)-tetrahydropyranyl-substituted 1,3,4-Oxadiazoles
Aghekyan, А.А.,Mkryan, G. G.,Panosyan, H. A.,Safaryan, A. S.,Stepanyan, H. M.
, p. 281 - 286 (2020)
Abstract: Condensation of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonyl chloride with hydrazine hydrate, furan-2- and 2,5-dimethylfuran-2carbohydrazides gave disubstituted hydrazides, whose cyclization formed symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. Ethyl 4-[4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-carboxamido]benzoate was reacted with hydrazine to obtain N-[4-(hydrazinocarbonyl)-phenyl]-4-(4-methoxphenyl)tetrahydro-2H-pyran-4-carboxamide. Treatment of the latter with triethyl orthoformate gave a monosubstituted 1,3,4-oxadiazole, and with carbon disulfide, a 5-sulfanyl-1,3,4-oxadiazole derivative was obtained. The subsequent alkylation of this derivative with 5-metoxyfuran-2-methyl and benzylaminocarbonylmethyl chlorides substituted chlorides resulted in the synthesis of the corresponding novel S-substituted oxadiazole derivatives. The synthesized compounds were tested for antibacterial activity.
EP300/CREBBP INHIBITOR
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, (2020/05/30)
The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.
Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine
Agekyan,Mkryan
, p. 1057 - 1062 (2015/06/25)
Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acyl
NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF
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, (2008/12/06)
Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.
