3648-78-0

Basic information

• Product Name: 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile
• Synonyms: 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile;4-(4-Methoxyphenyl)oxane-4-carbonitrile
• CAS NO: 3648-78-0
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.2637
• Mol File: 3648-78-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 130 °C(Press: 0.15 Torr)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile(3648-78-0)
• EPA Substance Registry System: 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile(3648-78-0)

Safety Data

• Hazardous Substances Data: 3648-78-0(Hazardous Substances Data)

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 104-47-2 p-methoxybenzylnitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 

Downstream Products

• 3648-58-6 4-(4-methoxyphenyl)-tetrahydro-2-pyran-4-carboxylic acid 
• 1035261-19-8 diethyl 2-(4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate 
• 664993-53-7 N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide 
• 694485-33-1 N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethyl]carbamoylphenyl}benzamide 
• 664993-51-5 4-(4-methoxyphenyl)-N-[4-(2-methoxy-5-methylphenylcarbamoyl)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 573949-85-6 4-(4-methoxyphenyl)-N-[4-(morpholin-4-ylcarbonyl)-phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 885561-38-6 ethyl 4-[(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoate 
• 4035-86-3 4-(4-methoxyphenyl)tetrahydro-2-pyran-4-carbonyl chloride 
• 440087-51-4 1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine 
• 868849-45-0 4-(4-hydroxy-phenyl)-tetrahydro-pyran-4-carbonitrile 

Relevant articles and documents

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acyl

3- Or 4-monosubstituted phenol derivatives useful as H3 ligands

The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.