Technology Process of 2-(2-bromo-3-methoxymethoxymethyl-phenyl)-[1,3]dioxolane
There total 7 articles about 2-(2-bromo-3-methoxymethoxymethyl-phenyl)-[1,3]dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 9 h / 100 °C
1.2: 2 h / 20 - 25 °C
2.1: lithium borohydride / diethyl ether; tetrahydrofuran / 20 - 25 °C
2.2: pH 6 - 7
3.1: silica gel; pyridinium chlorochromate / dichloromethane / 20 - 25 °C
4.1: toluene-4-sulfonic acid / toluene / Reflux
4.2: 2 h / Reflux
5.1: sodium tetrahydroborate / methanol / 1 h / 20 - 25 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / 20 - 25 °C
With
sodium tetrahydroborate; lithium borohydride; thionyl chloride; silica gel; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silica gel; pyridinium chlorochromate / dichloromethane / 20 - 25 °C
2.1: toluene-4-sulfonic acid / toluene / Reflux
2.2: 2 h / Reflux
3.1: sodium tetrahydroborate / methanol / 1 h / 20 - 25 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / 20 - 25 °C
With
sodium tetrahydroborate; silica gel; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate;
In
methanol; dichloromethane; toluene;
