1-fluoro-4-(trifluoromethyl)naphthalene

Base Information

• Chemical Name: 1-fluoro-4-(trifluoromethyl)naphthalene
• CAS No.: 59080-13-6
• Molecular Formula: C11H6 F4
• Molecular Weight: 214.162
• Hs Code.: 2903999090
• Mol file: 59080-13-6.mol

Synonyms:1-Fluoro-4-(trifluoromethyl)naphthalene;4-(Trifluoromethyl)-1-fluoronaphthalene

Chemical Property of 1-fluoro-4-(trifluoromethyl)naphthalene

Chemical Property:

• PSA: 0.00000
• LogP: 3.99770

Purity/Quality:

98%min ^*data from raw suppliers

1-Fluoro-4-(trifluoromethyl)naphthalene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-fluoro-4-(trifluoromethyl)naphthalene

There total 4 articles about 1-fluoro-4-(trifluoromethyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + 1-iodo-4-fluoronaphthalene (17318-09-1) → 1-fluoro-4-trifluoromethyl-naphthalene (59080-13-6)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 75 ℃; for 12h;

Reference yield:

1-iodo-4-fluoronaphthalene (17318-09-1) → 1-fluoro-4-trifluoromethyl-naphthalene (59080-13-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 75 ℃; for 12h; sealed tube;

Reference yield:

4-fluoro-1-naphthoic acid (573-03-5) → 1-fluoro-4-trifluoromethyl-naphthalene (59080-13-6)

Guidance literature:

With sulfur tetrafluoride; (heating);

DOI:10.1021/ja00423a012

upstream raw materials:

4-fluoro-1-naphthoic acid

1-iodo-4-fluoronaphthalene

2,2-difluoro-2-(fluorosulfonyl)acetate

Refernces

• 1、 -. "ANTIDIABETIC BICYCLIC COMPOUNDS". Page/Page column 16. . Retrieved 2008/06/13.