1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone

Base Information

Chemical Name:1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone
CAS No.:140865-97-0
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:
DSSTox Substance ID:DTXSID50696755
Wikidata:Q82626451
Mol file:140865-97-0.mol

Synonyms:140865-97-0;1-(8-HYDROXY-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)ETHANONE;1-(8-hydroxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone;2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol;1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one;Ethanone,1-(3,4-dihydro-8-hydroxy-2(1H)-isoquinolinyl)-;SCHEMBL17197242;DTXSID50696755;AKOS006315989;CS-0357913;FT-0661378;A807697;1-(8-oxidanyl-3,4-dihydro-1H-isoquinolin-2-yl)ethanone

Suppliers and Price of 1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
2mg
$ 65.00

TRC
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
25mg
$ 690.00

TRC
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
50mg
$ 1230.00

Medical Isotopes, Inc.
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
50 mg
$ 2620.00

Medical Isotopes, Inc.
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
5 mg
$ 890.00

Biosynth Carbosynth
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
2 mg
$ 140.00

Biosynth Carbosynth
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
5 mg
$ 300.00

Biosynth Carbosynth
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
10 mg
$ 540.00

Biosynth Carbosynth
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
25 mg
$ 1025.00

Biosynth Carbosynth
2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol
50 mg
$ 1650.00

Total 5 raw suppliers

Chemical Property of 1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone

Chemical Property:

Boiling Point:395.1±42.0 °C(Predicted)
PKA:9.74±0.20(Predicted)
PSA：40.54000
Density:1.217±0.06 g/cm3(Predicted)
LogP:1.23470
Solubility.:Acetone, Chloroform, Dichloromethane
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:229

Purity/Quality:

97% ^*data from raw suppliers

2-Acetyl-1,2,3,4-tetrahydro-8-isoquinolinol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CCC2=C(C1)C(=CC=C2)O
Uses 1-(8-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone is used in the synthesis of tetrahydroisoquinoline derivatives.

Technology Process of 1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone

There total 3 articles about 1-(8-Hydroxy-3,4-dihydroisoquinolin-2(1H)-YL)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-acetyl-1,2,3,4-tetrahydroisoquinoline-8-yl acetate

: 140865-97-0
1-(8-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 8h;

Reference yield:

: 3482-14-2
isoquinolin-8-ol

: 140865-97-0
1-(8-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tetrahydroborate / 1 h / 20 °C / Cooling

2: triethylamine / dichloromethane / 2 h / 20 °C / Cooling

3: sodium hydroxide; methanol / 8 h / 20 °C

With methanol; sodium tetrahydroborate; acetic acid; triethylamine; sodium hydroxide; In dichloromethane;

Reference yield:

: 32999-37-4
1,2,3,4-tetrahydroisoquinoline-8-ol

: 140865-97-0
1-(8-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling

2: sodium hydroxide; methanol / 8 h / 20 °C

With methanol; triethylamine; sodium hydroxide; In dichloromethane;