1,2,3,4-Tetrahydroisoquinolin-8-ol

Base Information

Chemical Name:1,2,3,4-Tetrahydroisoquinolin-8-ol
CAS No.:32999-37-4
Molecular Formula:C9H11NO
Molecular Weight:149.192
Hs Code.:2933499090
ChEMBL ID:CHEMBL69312
DSSTox Substance ID:DTXSID80545540
Wikidata:Q72505927
Mol file:32999-37-4.mol

Synonyms:1,2,3,4-tetrahydroisoquinolin-8-ol;32999-37-4;1,2,3,4-Tetrahydro-isoquinolin-8-ol;8-Hydroxy-1,2,3,4-tetrahydroisoquinoline;CHEMBL69312;8-Isoquinolinol, 1,2,3,4-tetrahydro-;8-Hydroxy-1,2,34-tetrahydroisoquinoline;8-hydroxytetrahydroisoquinoline;SCHEMBL3157785;DTXSID80545540;UHEOSCFYXMSUPR-UHFFFAOYSA-N;BDBM50024836;AKOS006304408;DS-2445;SB36632;AM806859;CS-0138849;A26325;F19176;EN300-2967077

Suppliers and Price of 1,2,3,4-Tetrahydroisoquinolin-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-8-ol 95%
1g
$ 398.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-8-ol 95%
500mg
$ 249.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-8-ol 95%
100mg
$ 137.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-8-ol 95%
250mg
$ 175.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-8-ol 95%
5g
$ 1390.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-8-ol 95+%
10g
$ 1906.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-8-ol 95+%
5g
$ 1141.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-8-ol 95+%
250mg
$ 151.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-8-ol 95+%
100mg
$ 94.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-8-ol 95+%
1g
$ 376.00

Total 21 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydroisoquinolin-8-ol

Chemical Property:

Boiling Point:294.3±40.0 °C(Predicted)
PKA:9.21±0.20(Predicted)
PSA：32.26000
Density:1.141±0.06 g/cm3(Predicted)
LogP:1.36670
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:149.084063974
Heavy Atom Count:11
Complexity:138

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-Tetrahydro-isoquinolin-8-ol 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=C1C=CC=C2O

Technology Process of 1,2,3,4-Tetrahydroisoquinolin-8-ol

There total 6 articles about 1,2,3,4-Tetrahydroisoquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 3482-14-2
isoquinolin-8-ol

: 32999-37-4
1,2,3,4-tetrahydroisoquinoline-8-ol

Guidance literature:: With sodium tetrahydroborate; acetic acid; at 20 ℃; for 1h; Cooling;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 3458-98-8
3-hydroxyphenylethylamine hydrochloride

: 14446-24-3
6-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 32999-37-4
1,2,3,4-tetrahydroisoquinoline-8-ol

Guidance literature:: In water; at 20 ℃;
DOI:10.1021/jo00365a041

Reference yield:

: 536-21-0
norfenefrine

: 32999-37-4
1,2,3,4-tetrahydroisoquinoline-8-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / H₂ / 10percent Pd/C / aq. HCl / 30 h / 775.7 - 1810.02 Torr

2: H₂O / 20 °C / other 3-hydroxyphenethylamines, other aldehydes; var. pH

With hydrogen; palladium on activated charcoal; In hydrogenchloride; water;
DOI:10.1021/jo00365a041