32999-37-4 Usage
Uses
Used in Medicinal Chemistry:
1,2,3,4-Tetrahydro-isoquinolin-8-ol is used as an intermediate in the synthesis of bioactive compounds and pharmaceuticals for its potential pharmacological properties.
Used in Drug Development:
THIQ-8-ol is utilized as a building block in the development of new drugs, owing to its chemical structure and reactivity, which contribute to the creation of various organic compounds with potential therapeutic applications.
Used in Neuroprotection:
1,2,3,4-Tetrahydro-isoquinolin-8-ol is used as a neuroprotective agent due to its potential to protect neurons from damage or degeneration, which can be beneficial in the treatment of neurological disorders.
Used in Antioxidant Therapy:
THIQ-8-ol is employed as an antioxidant, helping to neutralize harmful free radicals and prevent oxidative stress, which can contribute to various diseases and aging processes.
Used in Chemical Synthesis:
1,2,3,4-Tetrahydro-isoquinolin-8-ol serves as a versatile building block in chemical synthesis, enabling the creation of a wide range of organic compounds for various applications in research and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 32999-37-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,9,9 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 32999-37:
(7*3)+(6*2)+(5*9)+(4*9)+(3*9)+(2*3)+(1*7)=154
154 % 10 = 4
So 32999-37-4 is a valid CAS Registry Number.
32999-37-4Relevant academic research and scientific papers
Tyrosine Kinase Inhibitor And Uses Thereof
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Paragraph 0455-0456, (2017/05/15)
Disclosed is a compound of Formula (I) or a pharmaceutically acceptable salt, ester, or solvate thereof, or their stereoisomers, which can be used as tyrosine kinase inhibitor. Also disclosed is a method for preparing the compound, a pharmaceutical composition and a kit comprising the compound, and uses of the compound. The compound can be used as tyrosine kinase inhibitor, or can be used to reduce or inhibit activity of EGFR or mutant thereof, such as EGFR mutant comprising T790M mutation, in a cell, or to treat and/or prevent a disease associated with overactivity of EGFR, such as cancer.
Synthesis and SAR of novel histamine H3 receptor antagonists
Jesudason, Cynthia D.,Beavers, Lisa S.,Cramer, Jeffrey W.,Dill, Joelle,Finley, Don R.,Lindsley, Craig W.,Stevens, F. Craig,Gadski, Robert A.,Oldham, Samuel W.,Pickard, R. Todd,Siedem, Christopher S.,Sindelar, Dana K.,Singh, Ajay,Watson, Brian M.,Hipskind, Philip A.
, p. 3415 - 3418 (2007/10/03)
The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H3 receptors are reported.
