2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

Base Information

Chemical Name:2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol
CAS No.:1360460-64-5
Molecular Formula:C₃₀H₃₃NO₂
Molecular Weight:439.598
Hs Code.:

Synonyms:2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

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Chemical Property of 2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

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Technology Process of 2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

There total 3 articles about 2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1360460-67-8
1-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-phenylethanone

: 1360460-64-5
2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.12.008

Reference yield:

: 1210-33-9
5-chlorodibenzosuberane

: 1360460-64-5
2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 20 °C

2: potassium permanganate; potassium hydroxide / pyridine; water / 5 h / 20 °C / Cooling with ice

3: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; lithium aluminium tetrahydride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.12.008

Reference yield:

: 120-29-6
3-tropanol

: 1360460-64-5
2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 20 °C

2: potassium permanganate; potassium hydroxide / pyridine; water / 5 h / 20 °C / Cooling with ice

3: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; lithium aluminium tetrahydride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.12.008