methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Base Information

Chemical Name:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate
CAS No.:861676-19-9
Molecular Formula:C₁₉H₂₈N₂O₅
Molecular Weight:364.442
Hs Code.:

Synonyms:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

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Chemical Property of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

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Technology Process of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

There total 5 articles about methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 623950-04-9
4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester

: 593-51-1
methylamine hydrochloride

: 861676-19-9
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Guidance literature:: With ammonium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; tert-butyl alcohol; at 20 ℃; for 0.666667h;
DOI:10.1016/j.tet.2005.04.065

Reference yield: 78.0%

: 4-bromo-N,3,5-trimethylbenzamide

: 93267-04-0,170848-34-7,889670-02-4
N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

: 861676-19-9
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Guidance literature:: N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-bromo-N,3,5-trimethylbenzamide; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield:

: 623950-03-8
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

: 861676-19-9
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃; palladium (II) acetate; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 8 h / 60 °C

2: 100 percent / ammonium chloride; PyBOP; DIPEA / dimethylformamide; 2-methyl-propan-2-ol / 0.67 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; ammonium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tet.2005.04.065