4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride

Base Information

• Chemical Name: 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride
• CAS No.: 245745-65-7
• Molecular Formula: C₁₇H₁₀F₆N₄O
• Molecular Weight: 400.283
• Mol file: 245745-65-7.mol

Synonyms:4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride

Chemical Property of 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride

There total 8 articles about 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyridine-4-carboxylic acid (55-22-1) + 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline (123066-64-8) → 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride (245745-65-7)

Guidance literature:

With phosphorus trichloride; In acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/jo2009824

Reference yield:

1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (123066-63-7) → 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride (245745-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate

2: EDC; DMAP

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethyl acetate; 1: Reduction / 2: Condensation;

DOI:10.1021/jm990615a

Reference yield:

1,1,1,5,5,5-hexafluoroacetylacetone (1522-22-1) → 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride (245745-65-7)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / ethanol / Heating

2: H₂ / Pd/C / ethyl acetate

3: EDC; DMAP

With hydrogenchloride; dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; ethyl acetate; 1: cyclocondensation / 2: Reduction / 3: Condensation;

DOI:10.1021/jm990615a

upstream raw materials:

pyridine-4-carboxylic acid

4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

4-(chlorocarbonyl)pyridine

1,1,1,5,5,5-hexafluoroacetylacetone