123066-63-7

Basic information

• Product Name: 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE
• Synonyms: 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE;1-(4-Nitrophenyl)-3,5-bis(trifluoroMethyl)-1H-pyrazole
• CAS NO: 123066-63-7
• Molecular Formula: C₁₁H₅F₆N₃O₂
• Molecular Weight: 325.17
• Mol File: 123066-63-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE(123066-63-7)
• EPA Substance Registry System: 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE(123066-63-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 123066-63-7(Hazardous Substances Data)

Usage

General Description

1-(4-Nitrophenyl)-3,5-di(trifluoromethyl)-1H-pyrazole is a chemical compound with the molecular formula C11H6F6N4O2. It is a pyrazole derivative with a nitrophenyl group and two trifluoromethyl substituents. 1-(4-NITROPHENYL)-3,5-DI(TRIFLUOROMETHYL)-1H-PYRAZOLE has potential applications in the field of pharmaceuticals and agrochemicals due to its unique structure and properties. It may be used in the synthesis of other organic compounds and may have biological activities that make it useful for certain medicinal or agricultural purposes. Further research and testing are necessary to fully understand the potential uses and effects of this chemical.

Upstream product

• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 1522-22-1 1,1,1,5,5,5-hexafluoroacetylacetone 
• 1694-30-0 1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one 
• 100-16-3 4-nitrophenylhydrazone 

Downstream Products

• 1101891-14-8 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide 
• 1315322-99-6 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide 
• 1315323-00-2 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-4-methylbenzenesulfonamide 
• 245747-08-4 N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-3-fluoroisonicotinamide 
• 245745-65-7 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]isonicotinanilide monohydrochloride 
• 123066-64-8 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline 

Relevant articles and documents

Formation and dehydration of a series of 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles

Reaction of five (3-oxo-4,4,4-trifluorobutanoyl)heterocycles with hydrazine hydrate under mild conditions gave the corresponding 3-heterocyclyl-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazoles. Thermal elimination of water from the 3-(thien-2-yl), 3-(pyridin-2-yl) and 3-(pyridin-4-yl) compounds readily gave the corresponding pyrazoles but acid catalysis was required to form 3-(benzothiazol-2-yl)-5-trifluoromethylpyrazole and 3-(1-methylbenzimidazol-2-yl)-5-trifluoromethylpyrazole. More forcing conditions were required for the analogous dehydration/aromatisations giving 3,5-bis(trifluoromethyl)-1-(4-nitrophenyl)pyrazole and 3,5-bis(trifluoromethyl)-1-pentafluorophenylpyrazole.

MODULATORS OF SOCE, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) able to modulate Store Operated Calcium Entry (SOCE). The disclosure also relates to the use of compounds of formula (I) for treatment of pathological conditions in which SOCE modulation might be beneficial, such as neglecting dis

Synthesis of fluorinated heterocycles

Selected 1,3-diketones having a trifluoromethyl group and/or a fluorine in the 2-position were condensed with aromatic hydrazines, hydroxylamine, urea, thiourea, guanidine, and substituted anilines producing pyrazoles, isoxazoles, pyrimidines, and quinolines, respectively, in yields ranging from 27 to 87%.