2-Cyclopentylethanamine

Base Information

• Chemical Name: 2-Cyclopentylethanamine
• CAS No.: 5763-55-3
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Hs Code.: 2921300090
• European Community (EC) Number: 848-174-4
• DSSTox Substance ID: DTXSID30415461
• Nikkaji Number: J718.937K
• Wikidata: Q72460434
• Mol file: 5763-55-3.mol

Synonyms:2-cyclopentylethanamine;5763-55-3;2-Cyclopentylethylamine;2-Cyclopentyl-ethylamine;(2-Cyclopentylethyl)amine;Cyclopentaneethanamine;2-cyclopentylethan-1-amine;2-cyclopentyl ethylamine;2-cyclopentylethyl amine;SCHEMBL919957;DTXSID30415461;UKPLRVAKKXWITN-UHFFFAOYSA-N;2-CYCLOPENTYL-1-ETHANAMINE;2-cyclopentylethanamine, AldrichCPR;MFCD00058672;STK664197;AKOS000164317;AB02350;CCG-358828;GS-6124;BP-11077;AM20100413;BB 0237096;CS-0197300;FT-0648635;EN300-30612;AB01007442-01

Chemical Property of 2-Cyclopentylethanamine

Chemical Property:

• Vapor Pressure: 5.09mmHg at 25°C
• Refractive Index: 1.464
• Boiling Point: 144.4 °C at 760 mmHg
• PKA: 10.72±0.10(Predicted)
• Flash Point: 35.4 °C
• PSA: 26.02000
• Density: 0.871 g/cm³
• LogP: 2.22570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 55.4

Purity/Quality:

99% ^*data from raw suppliers

2-Cyclopentylethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)CCN

Technology Process of 2-Cyclopentylethanamine

There total 7 articles about 2-Cyclopentylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-cyclopentylacetamide (933-04-0) → 2-cyclopentylethan-1-amine (5763-55-3)

Guidance literature:

In diethyl ether;

Reference yield:

2-cyclopentylacetic acid (1123-00-8) → 2-cyclopentylethan-1-amine (5763-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 25 °C

2: ammonia / tetrahydrofuran; water / 0 - 25 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere; Schlenk technique

With lithium aluminium tetrahydride; oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/acs.orglett.9b00553

Reference yield:

2-(cyclopent-1-en-1-yl) ethan-1-amine (3197-72-6) → 2-cyclopentylethan-1-amine (5763-55-3)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 1.5h; under 760.051 Torr;

DOI:10.1016/j.molliq.2019.111967

upstream raw materials:

2-cyclopentylacetonitrile

chloromethylcyclopentane

2-cyclopentylacetamide

2-cyclopentylacetic acid

Downstream raw materials:

2-(Cyclopentyl)-ethyl-isothiocyanat

6-[4-((2-cyclopentyl-ethyamino)-methyl)-2-ethoxyphenoxy]nicotinonitrile

N-(2-cyclopentyl-ethyl)-benzamide

Refernces

• 1、 Hu, Qu-Ping,Cheng, Jing,Wang, Ying,Shi, Jie,Wang, Bi-Qin,Hu, Ping,Zhao, Ke-Qing,Pan, Fei. "Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes". supporting information. p. 4457 - 4462. Retrieved 2021/05/26.
• 2、 Diler, Fatma,Burhan, Hakan,Genc, Hayriye,Kuyuldar, Esra,Zengin, Mustafa,Cellat, Kemal,Sen, Fatih. "Efficient preparation and application of monodisperse palladium loaded graphene oxide as a reusable and effective heterogeneous catalyst for suzuki cross-coupling reaction". . . Retrieved 2019/11/29.