2-PROPENOIC ACID, 3-(3-THIENYL)-, ETHYL ESTER

Base Information

• Chemical Name: 2-PROPENOIC ACID, 3-(3-THIENYL)-, ETHYL ESTER
• CAS No.: 50266-60-9
• Molecular Formula: C9H10 O2 S
• Molecular Weight: 182.243
• Hs Code.: 2934999090
• Mol file: 50266-60-9.mol

Synonyms:3-Thiopheneacrylicacid, ethyl ester (6CI); Ethyl 3-(3-thienyl)prop-2-enoate

Chemical Property of 2-PROPENOIC ACID, 3-(3-THIENYL)-, ETHYL ESTER

Chemical Property:

• PSA: 54.54000
• LogP: 2.32440

Purity/Quality:

99% ^*data from raw suppliers

(E)-Ethyl3-(thiophen-3-yl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PROPENOIC ACID, 3-(3-THIENYL)-, ETHYL ESTER

There total 16 articles about 2-PROPENOIC ACID, 3-(3-THIENYL)-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-thiophene carboxaldehyde (498-62-4) + diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) → (E)-3-thiophen-3-yl-acrylic acid ethyl ester (50266-60-9)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

3-thiophene carboxaldehyde; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

DOI:10.1002/pola.25842

Reference yield: 95.0%

3-thiophene carboxaldehyde (498-62-4) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-3-thiophen-3-yl-acrylic acid ethyl ester (50266-60-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.009

Reference yield: 95.0%

3-thiophene carboxaldehyde (498-62-4) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl (2E)-3-(3-thienyl)propenoate (50266-60-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

3-thiophene carboxaldehyde

hydrogen ethyl malonate

ethanol

trans-3-(3-thienyl)acrylic acid

Downstream raw materials:

C₃₆H₅₀O₂S₂

3-(3-thienyl)-propyl alcohol

(S)-3-phenyl-3-(thiophen-3-yl)propan-1-ol

C₁₃H₁₂S