methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Base Information

Chemical Name:methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine
CAS No.:190446-44-7
Molecular Formula:C₂₁H₂₉N₅O₆
Molecular Weight:447.491
Hs Code.:

methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Synonyms:methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Suppliers and Price of methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

There total 7 articles about methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 190446-43-6
(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-benzyloxycarbonylamino-propionic acid methyl ester

: 190446-44-7
methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Guidance literature:: With cyclohexa-1,4-diene; palladium on activated charcoal; In methanol; for 0.5h; Ambient temperature;
DOI:10.1021/jm960799i

Reference yield:

: 52707-54-7,52707-59-2,64847-77-4
4-cyanobenzaldehyde oxime

: 190446-44-7
methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Guidance literature:: Multi-step reaction with 7 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

5: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

6: 89 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafkuoroborate, Et₃N / dimethylformamide / 16 h / Ambient temperature

7: 62 percent / 1,4-cyclohexadiene / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; sodium hypochlorite; cyclohexa-1,4-diene; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-13-7
[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid

: 190446-44-7
methyl 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)amino]-N-[(phenylmethoxy)carbonyl]-L-alanine

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

4: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

5: 89 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafkuoroborate, Et₃N / dimethylformamide / 16 h / Ambient temperature

6: 62 percent / 1,4-cyclohexadiene / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; cyclohexa-1,4-diene; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i