N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

Base Information

Chemical Name:N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide
CAS No.:1382991-38-9
Molecular Formula:C₂₇H₂₇Cl₂FN₂OSi
Molecular Weight:513.514
Hs Code.:

Synonyms:N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

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Chemical Property of N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

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Technology Process of N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

There total 9 articles about N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1382991-37-8
3-(3-fluorobenzyl)-N-(4-(trimethylsilyl)but-3-ynyl)benzamide

: 697-90-5
2,4-dichloro-6-iodoaniline

: 1382991-38-9
N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

Guidance literature:: With sodium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Sealed tube;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1382991-38-9
N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Microwave irradiation

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed tube

With water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1382991-38-9
N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Microwave irradiation

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed tube

With water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;