butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate

Base Information

• Chemical Name: butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate
• CAS No.: 552336-93-3
• Molecular Formula: C₂₀H₂₀N₄O₆
• Molecular Weight: 412.402
• Mol file: 552336-93-3.mol

Synonyms:butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate

Chemical Property of butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate

There total 3 articles about butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-5-nitropyridine (4548-45-2) + ethyl 3-(4-methylphenyl)amino-5-oxo-2,5-dihydroisoxazole-4-carboxylate + butan-1-ol (71-36-3) → butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate (552336-93-3)

Guidance literature:

In butan-1-ol; for 12h; Heating;

DOI:10.3390/71200907

Reference yield:

diethyl (4-methylphenyl)thiocarbamamoylmalonate (3288-13-9) → butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate (552336-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / hydroxylamine hydrochloride; NaHCO₃ / ethanol; H₂O / 24 h / 20 °C

2: 80 percent / butan-1-ol / 12 h / Heating

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; butan-1-ol;

DOI:10.3390/71200907

Reference yield:

diethyl malonate (105-53-3) → butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate (552336-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium; ethanol / 0.25 h / 20 °C

1.2: 90 percent / ethanol / 2 h / 20 °C

2.1: 85 percent / hydroxylamine hydrochloride; NaHCO₃ / ethanol; H₂O / 24 h / 20 °C

3.1: 80 percent / butan-1-ol / 12 h / Heating

With ethanol; hydroxylamine hydrochloride; sodium; sodium hydrogencarbonate; In ethanol; water; butan-1-ol;

DOI:10.3390/71200907

upstream raw materials:

2-chloro-5-nitropyridine

butan-1-ol

diethyl (4-methylphenyl)thiocarbamamoylmalonate

diethyl malonate