3288-13-9

Basic information

• Product Name: diethyl (4-methylphenyl)thiocarbamamoylmalonate
• Synonyms: diethyl (4-methylphenyl)thiocarbamamoylmalonate
• CAS NO: 3288-13-9
• Molecular Weight: 309.386
• Mol File: 3288-13-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl (4-methylphenyl)thiocarbamamoylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-methylphenyl)thiocarbamamoylmalonate(3288-13-9)
• EPA Substance Registry System: diethyl (4-methylphenyl)thiocarbamamoylmalonate(3288-13-9)

Safety Data

• Hazardous Substances Data: 3288-13-9(Hazardous Substances Data)

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 105-53-3 diethyl malonate 

Downstream Products

• 506436-27-7 ethyl 3-(4-methylphenyl)amino-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 1271133-61-9 ethyl 5-oxo-2-(pyrimidin-2-yl)-3-(p-tolylamino)-2,5-dihydroisoxazole-4-carboxylate 
• 1271133-91-5 ethyl 2-(p-tolylamino)imidazo[1,2-a]pyrimidine-3-carboxylate 
• 945917-86-2 ethyl 2-(benzoxazol-2-yl)-3-(4-methylphenylamino)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 948905-03-1 ethyl 2-(benzothiazol-2-yl)-3-(4-methylphenyl)amino-5-oxo-2, 5-dihydroisoxazole-4-carboxylate 
• 2941-71-1 2,6-dimethylbenzothiazole 
• 552336-93-3 butyl 3-(4-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 506436-33-5 ethyl 3-(4-methylphenyl)amino-2-(5-nitropyridin-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 53884-10-9 2-[(2-Nitro-phenyldisulfanyl)-p-tolylamino-methylene]-malonic acid diethyl ester 
• 7171-48-4 (4-phenyl-3-p-tolyl-3H-thiazol-2-ylidene)-malonic acid diethyl ester 

Relevant articles and documents

Rearrangements of 2-pyridyl-3-arylaminoisoxazol-5(2H)-ones to imidazo[1,2-a]pyridines under flash-vacuum-pyrolysis

2-Pyridyl-3-arylaminoisoxazol-5(2H)-ones, rearranged under flash-vacuum-pyrolysis (FVP) conditions accompanied by elimination of carbon dioxide to give imidazo[1,2-a]pyridines in high to excellent yields (85-95 %).

2-Aryl-3-arylaminoisoxazol-5(2H)-ones as sources of indoles and imidazo[1,2-a]pyridines

2-Aryl-3-arylaminoisoxazol-5(2H)-ones undergo solvolysis to form 1,3-dipoles that undergo intramolecular cyclisation to form either imidazopyridines or indoles. The mode of cyclisation is controlled by the electronegativity of the aryl substituents.