1-(2-Amino-5-methoxy-phenyl)-ethanone

Base Information

• Chemical Name: 1-(2-Amino-5-methoxy-phenyl)-ethanone
• CAS No.: 23042-77-5
• Molecular Formula: C14H13NO2
• Molecular Weight: 165.192
• Hs Code.: 2922509090
• Mol file: 23042-77-5.mol

Synonyms:Acetophenone, 2'-amino-5'-methoxy- (8CI);2'-Amino-5'-methoxyacetophenone;

Chemical Property of 1-(2-Amino-5-methoxy-phenyl)-ethanone

Chemical Property:

• Boiling Point: 428.326 °C at 760 mmHg
• Flash Point: 219.55 °C
• PSA: 52.32000
• Density: 1.172 g/cm³
• LogP: 2.06120

Purity/Quality:

97% ^*data from raw suppliers

1-(2-amino-5-methoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Amino-5-methoxy-phenyl)-ethanone

There total 30 articles about 1-(2-Amino-5-methoxy-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl 2-acetyl-4-methoxyphenylcarbamate (1335060-62-2) → 1-(2-amino-5-methoxy-phenyl)-ethanone (23042-77-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 18h;

DOI:10.1016/j.tet.2011.07.090

Reference yield: 99.0%

4-methoxyacetanilide (51-66-1) → 1-(2-amino-5-methoxy-phenyl)-ethanone (23042-77-5)

Guidance literature:

With cetyltrimethylammonim bromide; In water; at 25 ℃; Reagent/catalyst; regioselective reaction; Irradiation; Micellar solution; Inert atmosphere;

DOI:10.1039/c5pp00349k

Reference yield: 97.0%

1-(5-methoxy-2-nitrophenyl)ethanone (42887-67-2) → 1-(2-amino-5-methoxy-phenyl)-ethanone (23042-77-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 760 Torr;

upstream raw materials:

N-(2-acetyl-4-methoxyphenyl)acetamide

1-(5-methoxy-2-nitrophenyl)ethanone

5-methoxy-2-<(4-methoxybenzoyl)amino>acetophenone

4-methoxy-aniline

Downstream raw materials:

6-(2-acetyl-4-methoxy-phenylamino)quinoline-5,8-dione

2-(2-amino-5-methoxyphenyl)propan-2-ol

(2-acetyl-4-methoxy-phenyl)-carbamic acid ethyl ester

2-<(4-fluorobenzoyl)amino>-5-methoxyacetophenone