α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

Base Information

Chemical Name:α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile
CAS No.:167158-95-4
Molecular Formula:C₃₂H₃₈N₂O₄S
Molecular Weight:546.731
Hs Code.:

Synonyms:α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

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Chemical Property of α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

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Technology Process of α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

There total 6 articles about α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1011-42-3
6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 167159-64-0
α-(5-chloropentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile

: 167158-95-4
α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 167158-94-3
α-(3,4-dimethoxyphenyl)-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)isoquinolineheptanenitrile

: 167158-95-4
α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform; ethyl acetate;

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167158-95-4
α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 21 percent / diisopropylethylamine, NaI / acetonitrile / Heating

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile;
DOI:10.1021/jm9804477