7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

Base Information

Chemical Name:7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile
CAS No.:167158-97-6
Molecular Formula:C₃₄H₄₁ClN₂O₄S
Molecular Weight:609.23
Hs Code.:

Synonyms:7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

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Chemical Property of 7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

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Technology Process of 7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

There total 7 articles about 7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 80-41-1
2-chloroethyl tosylate

: 167158-95-4
α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile

: 167158-97-6
7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

Guidance literature:: With sodium hydroxide; In butanone; for 18h; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167158-97-6
7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 21 percent / diisopropylethylamine, NaI / acetonitrile / Heating

4: 42 percent / 1 N NaOH / butan-2-one / 18 h / Heating

With sodium hydroxide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; butanone;
DOI:10.1021/jm9804477

Reference yield:

: 1011-42-3
6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 167158-97-6
7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 21 percent / diisopropylethylamine, NaI / acetonitrile / Heating

2: 42 percent / 1 N NaOH / butan-2-one / 18 h / Heating

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; butanone;
DOI:10.1021/jm9804477