N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Base Information

Chemical Name:N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide
CAS No.:1299487-65-2
Molecular Formula:C₃₀H₃₀F₆N₂O₂
Molecular Weight:564.571
Hs Code.:

Synonyms:N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Suppliers and Price of N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

There total 5 articles about N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299487-38-9
2-(4-((4-(4-aminobenzyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 103-80-0
phenylacetyl chloride

: 1299487-65-2
N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 2609-49-6
diethyl p-nitrobenzylphosphonate

: 1299487-65-2
N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 5 h

4: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 2250.23 Torr

5: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; 5% Pd(II)/C(eggshell); In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1299487-65-2
N-(4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 5 h

4: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 2250.23 Torr

5: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; 5% Pd(II)/C(eggshell); In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;