(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

Base Information

Chemical Name:(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide
CAS No.:1562406-67-0
Molecular Formula:C₂₄H₃₁NO₂S
Molecular Weight:397.582
Hs Code.:

Synonyms:(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

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Technology Process of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

There total 7 articles about (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562406-65-8
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

: 1562406-67-0
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 45 ℃; for 1.5h;

Reference yield:

: 1314795-38-4
4-bromo-2-(3,3-dimethylbut-1-ynyl)thiophene

: 1562406-67-0
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

3: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 45 °C

With hydrogenchloride; copper(l) iodide; 2-acetylcyclohexanone; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 78-79-5,9003-31-0
isoprene

: 1562406-67-0
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: titanium tetrachloride / dichloromethane / -10 - -9 °C / Large scale

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 - 27 °C / Large scale

3: potassium phosphate; N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

5: hydrogenchloride; water / tetrahydrofuran / 1.5 h / 45 °C

With hydrogenchloride; potassium phosphate; oxalyl dichloride; lithium hydroxide monohydrate; water; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Diels-Alder Cycloaddition;