(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

Base Information

Chemical Name:(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide
CAS No.:1562406-65-8
Molecular Formula:C₂₆H₃₅NO₃S
Molecular Weight:441.635
Hs Code.:

Synonyms:(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

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Chemical Property of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

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Technology Process of (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

There total 4 articles about (R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263102-05-1
[5-(3,3-dimethylbut-1-ynyl)thiophen-3-yl]-(1,4-dioxaspiro[4.5]dec-8-yl)amine

: 1314795-37-3
(1R)-4-methylcyclohex-3-enecarboxylic acid chloride

: 1562406-65-8
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 0.416667h;

Reference yield:

: 1314795-38-4
4-bromo-2-(3,3-dimethylbut-1-ynyl)thiophene

: 1562406-65-8
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; caesium carbonate; 2-acetylcyclohexanone / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

With copper(l) iodide; 2-acetylcyclohexanone; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 78-79-5,9003-31-0
isoprene

: 1562406-65-8
(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(1,4-dioxaspiro[4.5]decan-8-yl)cyclohex-3-enecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: titanium tetrachloride / dichloromethane / -10 - -9 °C / Large scale

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 - 27 °C / Large scale

3: potassium phosphate; N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.42 h / 0 - 20 °C

With potassium phosphate; oxalyl dichloride; lithium hydroxide monohydrate; water; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Diels-Alder Cycloaddition;