4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Base Information

Chemical Name:4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline
CAS No.:1345843-23-3
Molecular Formula:C₂₁H₁₂ClFN₄
Molecular Weight:374.804
Hs Code.:

Synonyms:4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

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Technology Process of 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

There total 4 articles about 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1345843-61-9
4-(3-iodoimidazo[1,2-b]pyridazin-8-yl)isoquinoline

2-chloro-4-fluorophenylboronic acid: 313545-72-1
2-chloro-4-fluorophenylboronic acid

: 1345843-23-3
4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 20 - 85 ℃; Inert atmosphere;

Reference yield:

: 933190-51-3
8-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1345843-23-3
4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4.08 h / 20 - 100 °C / Microwave; Inert atmosphere

2: ammonium formate / 10 wt% Pd(OH)2 on carbon / ethanol / 0.42 h / 20 - 50 °C / Inert atmosphere

3: trifluoroacetic acid; N-iodo-succinimide / chloroform / 2 h / 20 °C

4: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 85 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; ammonium formate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; ethanol; chloroform; water; 4: Suzuki Coupling;

Reference yield:

: 1345843-59-5
4-(6-chloroimidazo[1,2-b]pyridazin-8-yl)isoquinoline

: 1345843-23-3
4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / 10 wt% Pd(OH)2 on carbon / ethanol / 0.42 h / 20 - 50 °C / Inert atmosphere

2: trifluoroacetic acid; N-iodo-succinimide / chloroform / 2 h / 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 85 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; ammonium formate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; ethanol; chloroform; water; 3: Suzuki Coupling;