4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Base Information

• Chemical Name: 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline
• CAS No.: 1345843-23-3
• Molecular Formula: C₂₁H₁₂ClFN₄
• Molecular Weight: 374.804
• Mol file: 1345843-23-3.mol

Synonyms:4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Chemical Property of 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

There total 4 articles about 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(3-iodoimidazo[1,2-b]pyridazin-8-yl)isoquinoline (1345843-61-9) + 2-chloro-4-fluorophenylboronic acid (313545-72-1) → 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline (1345843-23-3)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 20 - 85 ℃; Inert atmosphere;

Reference yield:

8-bromo-6-chloro-imidazo[1,2-b]pyridazine (933190-51-3) → 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline (1345843-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4.08 h / 20 - 100 °C / Microwave; Inert atmosphere

2: ammonium formate / 10 wt% Pd(OH)2 on carbon / ethanol / 0.42 h / 20 - 50 °C / Inert atmosphere

3: trifluoroacetic acid; N-iodo-succinimide / chloroform / 2 h / 20 °C

4: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 85 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; ammonium formate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; ethanol; chloroform; water; 4: Suzuki Coupling;

Reference yield:

4-(6-chloroimidazo[1,2-b]pyridazin-8-yl)isoquinoline (1345843-59-5) → 4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline (1345843-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate / 10 wt% Pd(OH)2 on carbon / ethanol / 0.42 h / 20 - 50 °C / Inert atmosphere

2: trifluoroacetic acid; N-iodo-succinimide / chloroform / 2 h / 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 85 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; ammonium formate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; ethanol; chloroform; water; 3: Suzuki Coupling;

upstream raw materials:

4-(3-iodoimidazo[1,2-b]pyridazin-8-yl)isoquinoline

2-chloro-4-fluorophenylboronic acid

8-bromo-6-chloro-imidazo[1,2-b]pyridazine

4-(6-chloroimidazo[1,2-b]pyridazin-8-yl)isoquinoline