3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Base Information

Chemical Name:3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole
CAS No.:1285575-50-9
Molecular Formula:C₂₃H₁₈F₃NO₃S
Molecular Weight:445.462
Hs Code.:

Synonyms:3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

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Chemical Property of 3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

There total 6 articles about 3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4433-52-7
2,3-dihydro-benzothiazole

: 1285575-48-5
4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl chloride

: 1285575-50-9
3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 100-39-0
benzyl bromide

: 1285575-50-9
3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 14 h

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 60 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 16 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With thionyl chloride; lithium hydroxide monohydrate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1285576-45-5
Ethyl 4-hydroxy-3-methoxy-5-trifluoromethyl benzoate

: 1285575-50-9
3-(4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 14 h

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 60 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 16 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With thionyl chloride; lithium hydroxide monohydrate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;