N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide

Base Information

• Chemical Name: N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide
• CAS No.: 812647-01-1
• Molecular Formula: C₉H₄F₆N₂O₆S
• Molecular Weight: 382.197
• Mol file: 812647-01-1.mol

Synonyms:N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide

Chemical Property of N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide

There total 2 articles about N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(2'-hydroxy-5'-nitrophenyl)trifluoroacetamide (170363-62-9) + N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) → N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide (812647-01-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 19h;

DOI:10.1016/j.tet.2004.09.034

Reference yield:

2-hydroxy-5-nitroaniline (99-57-0) → N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide (812647-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / pyridine / tetrahydrofuran / 16 h / 20 °C

2: 93 percent / NaH / tetrahydrofuran / 19 h / 20 °C

With pyridine; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tet.2004.09.034

Reference yield: 88.0%

N-[5'-nitro-2'-(((trifluoromethane)sulfonyl)oxy)phenyl]trifluoroacetamide (812647-01-1) + phenylacetylene (536-74-3) → 6-nitro-2-phenyl-1H-indole (500992-30-3)

Guidance literature:

With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 80 ℃; for 17h;

DOI:10.1016/j.tet.2004.09.034

upstream raw materials:

N-(2'-hydroxy-5'-nitrophenyl)trifluoroacetamide

N,N-phenylbistrifluoromethane-sulfonimide

2-hydroxy-5-nitroaniline

Downstream raw materials:

6-nitro-2-phenyl-1H-indole