(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

Base Information

Chemical Name:(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate
CAS No.:1059175-63-1
Molecular Formula:C₂₁H₂₆BrFN₂O₅
Molecular Weight:485.35
Hs Code.:

Synonyms:(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

Suppliers and Price of (E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

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Technology Process of (E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

There total 1 articles about (E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 321997-89-1
methyl 1-tert-butyloxycarbonyl-4-aminopiperidin-4-carboxylate

: 370867-85-9
3-(3-bromo-4-fluorophenyl)acrylic acid

: 1059175-63-1
(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 53.0%

: 1059175-63-1
(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate

: 74-88-4
methyl iodide

: 1059175-64-2
(E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)-N-methylacrylamido)piperidine-1,4-dicarboxylate

Guidance literature:: (E)-1-tert-butyl 4-methyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)piperidine-1,4-dicarboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 18h;