(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

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Chemical Name:(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide
CAS No.:171013-67-5
Molecular Formula:C₅₃H₈₅NO₇Si₃
Molecular Weight:932.517
Hs Code.:

(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

Synonyms:(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

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Chemical Property of (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

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Technology Process of (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

There total 29 articles about (R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (R)-N-[3-((Z)-1-Benzenesulfonyl-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

: 171013-67-5
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

Guidance literature:: With methanol; disodium hydrogenphosphate; sodium amalgam; at -20 ℃; for 0.25h;
DOI:10.1021/ja961401a

Reference yield:

: 180628-74-4
3-hydroxy-5-nitrobenzyl alcohol

: 171013-67-5
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / CBr₄, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

2: 75 percent / dimethylformamide / 15 h / 60 °C

3: 95 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

4: 100 percent / H₂ / 5percent Pd/C / methanol / 10 h

5: 1.) Me₃Al / 1.) C₆H₆, hexane, RT, 20 min, 2.) C₆H₆, hexane, RT, 21 h

6: 94 percent / imidazole / CH₂Cl₂ / 0.33 h / Ambient temperature

7: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C 10 min, 2.) THF, -78 deg C, 10 min

8: 94 percent / Na(Hg), Na₂HPO₄, MeOH / 0.25 h / -20 °C

With 1H-imidazole; methanol; disodium hydrogenphosphate; sodium amalgam; carbon tetrabromide; hydrogen; trimethylaluminum; sodium hexamethyldisilazane; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961401a

Reference yield:

: 78238-14-9
3-hydroxy-5-nitrobenzoic acid

: 171013-67-5
(R)-4-(tert-Butyl-dimethyl-silanyloxy)-N-[3-((Z)-4-{(4R,5S,6S)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-pent-3-enyl)-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-3-methoxy-butyramide

Guidance literature:: Multi-step reaction with 9 steps

1: 60 percent / BH₃*THF / tetrahydrofuran / 15 h / Ambient temperature

2: 85 percent / CBr₄, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

3: 75 percent / dimethylformamide / 15 h / 60 °C

4: 95 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

5: 100 percent / H₂ / 5percent Pd/C / methanol / 10 h

6: 1.) Me₃Al / 1.) C₆H₆, hexane, RT, 20 min, 2.) C₆H₆, hexane, RT, 21 h

7: 94 percent / imidazole / CH₂Cl₂ / 0.33 h / Ambient temperature

8: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C 10 min, 2.) THF, -78 deg C, 10 min

9: 94 percent / Na(Hg), Na₂HPO₄, MeOH / 0.25 h / -20 °C

With 1H-imidazole; methanol; disodium hydrogenphosphate; sodium amalgam; borane-THF; carbon tetrabromide; hydrogen; trimethylaluminum; sodium hexamethyldisilazane; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961401a