(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

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Chemical Name:(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide
CAS No.:171013-52-8
Molecular Formula:C₄₀H₅₃NO₆SSi₂
Molecular Weight:732.101
Hs Code.:

Synonyms:(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

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Chemical Property of (R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

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Technology Process of (R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

There total 7 articles about (R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 171013-51-7
(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-hydroxy-3-methoxy-butyramide

: 171013-52-8
(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

Guidance literature:: With 1H-imidazole;
DOI:10.1021/ja00148a034

Reference yield:

: 180628-74-4
3-hydroxy-5-nitrobenzyl alcohol

: 171013-52-8
(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / CBr₄, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

2: 75 percent / dimethylformamide / 15 h / 60 °C

3: 95 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

4: 100 percent / H₂ / 5percent Pd/C / methanol / 10 h

5: 1.) Me₃Al / 1.) C₆H₆, hexane, RT, 20 min, 2.) C₆H₆, hexane, RT, 21 h

6: 94 percent / imidazole / CH₂Cl₂ / 0.33 h / Ambient temperature

With 1H-imidazole; carbon tetrabromide; hydrogen; trimethylaluminum; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961401a

Reference yield:

: 78238-14-9
3-hydroxy-5-nitrobenzoic acid

: 171013-52-8
(R)-N-[3-Benzenesulfonylmethyl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / BH₃*THF / tetrahydrofuran / 15 h / Ambient temperature

2: 85 percent / CBr₄, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

3: 75 percent / dimethylformamide / 15 h / 60 °C

4: 95 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

5: 100 percent / H₂ / 5percent Pd/C / methanol / 10 h

6: 1.) Me₃Al / 1.) C₆H₆, hexane, RT, 20 min, 2.) C₆H₆, hexane, RT, 21 h

7: 94 percent / imidazole / CH₂Cl₂ / 0.33 h / Ambient temperature

With 1H-imidazole; borane-THF; carbon tetrabromide; hydrogen; trimethylaluminum; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja961401a