(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

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Chemical Name:(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole
CAS No.:1223405-42-2
Molecular Formula:C₁₆H₂₄FNOSi
Molecular Weight:293.457
Hs Code.:

Synonyms:(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

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Technology Process of (R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

There total 2 articles about (R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17318-03-5
bromo(3-fluorophenyl)magnesium

: 388582-04-5
(R)-(+)-4-chloro-3-hydroxybutyronitrile

: 1223405-42-2
(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

Guidance literature:: bromo(3-fluorophenyl)magnesium; (R)-(+)-4-chloro-3-hydroxybutyronitrile; In 1,2-dimethoxyethane; diethyl ether; ethanol; tert-butyl methyl ether;

With sodium hydroxide; In 1,2-dimethoxyethane; diethyl ether; ethanol; tert-butyl methyl ether; water; for 1h;

Reference yield:

: 56522-24-8
tert-butyldimethylsilyl cyanide

: 1223405-42-2
(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 15 h / 100 °C

2: diethyl ether; tert-butyl methyl ether / 2 h

In diethyl ether; tert-butyl methyl ether;

Reference yield: 77.1%

: 1223405-42-2
(R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole

: 1260846-33-0
(2R,4R)-4-(tert-butyldimethylsilyloxy)-2-(3-fluorophenyl)pyrrolidine

Guidance literature:: (R)-3-(tert-butyldimethylsilyloxy)-5-(3-fluorophenyl)-3,4-dihydro-2H-pyrrole; With sodium tetrahydroborate; acetic acid; In methanol; at -78 - 20 ℃;

With sodium hydroxide; In water; ethyl acetate;