4-Chloro-1,7-naphthyridine

Base Information

Chemical Name:4-Chloro-1,7-naphthyridine
CAS No.:16287-97-1
Molecular Formula:C₈H₅ClN₂
Molecular Weight:164.594
Hs Code.:2933998090
European Community (EC) Number:862-534-8
DSSTox Substance ID:DTXSID30483504
Wikidata:Q82320873
Mol file:16287-97-1.mol

Synonyms:4-Chloro-1,7-naphthyridine;16287-97-1;1,7-Naphthyridine, 4-chloro-;MFCD18382494;SCHEMBL8128;DTXSID30483504;AKOS016008216;PB25673;AS-41557;SY098417;CS-0050954;FT-0697783;EN300-220197;A882772

Suppliers and Price of 4-Chloro-1,7-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-1,7-naphthyridine
1g
$ 710.00

Matrix Scientific
4-Chloro-1,7-naphthyridine 95%
1g
$ 2016.00

Matrix Scientific
4-Chloro-1,7-naphthyridine 95%
500mg
$ 1250.00

Crysdot
4-Chloro-1,7-naphthyridine 95+%
1g
$ 675.00

Biosynth Carbosynth
4-Chloro-1,7-naphthyridine
1 g
$ 1300.00

Biosynth Carbosynth
4-Chloro-1,7-naphthyridine
500 mg
$ 1000.00

Biosynth Carbosynth
4-Chloro-1,7-naphthyridine
250 mg
$ 700.00

Biosynth Carbosynth
4-Chloro-1,7-naphthyridine
100 mg
$ 450.00

Biosynth Carbosynth
4-Chloro-1,7-naphthyridine
50 mg
$ 350.00

AK Scientific
4-Chloro-1,7-naphthyridine
100mg
$ 657.00

Total 26 raw suppliers

Chemical Property of 4-Chloro-1,7-naphthyridine

Chemical Property:

Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:164.0141259
Heavy Atom Count:11
Complexity:140

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-1,7-naphthyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CC2=NC=CC(=C21)Cl
Uses 4-Chloro-1,7-naphthyridine is a naphthyridine derivative for possible treatment of cell proliferative disorder.

Technology Process of 4-Chloro-1,7-naphthyridine

There total 11 articles about 4-Chloro-1,7-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54920-78-4
2,4-dichloro-[1,7]naphthyridine

: 16287-97-1
4-chloro-[1,7]naphthyridine

Guidance literature:: With propyl methanoate; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;

Reference yield:

: 60122-51-2
1,7-naphthyridin-4(1H)-one

: 16287-97-1
4-chloro-[1,7]naphthyridine

Guidance literature:: With trichlorophosphate;
DOI:10.1021/jo01377a019

Reference yield:

: 55279-30-6
methyl 3-aminoisonicotinate

: 16287-97-1
4-chloro-[1,7]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 18 h / 75 °C / Inert atmosphere

2.1: trichlorophosphate / toluene / 18 h / 80 °C

2.2: 20 °C

3.1: propyl methanoate; sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 72 h / 80 °C / Inert atmosphere

With propyl methanoate; potassium tert-butylate; sodium hydrogencarbonate; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; toluene;