60122-51-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-1,7-Naphthyridin-4-one is used as a key intermediate for the preparation of naphthyridine derivatives, which are valuable in the treatment of cell proliferative disorders. These derivatives have shown potential in targeting and managing various diseases characterized by abnormal cell growth, such as cancer.
In the preparation of naphthyridine derivatives, 1H-1,7-Naphthyridin-4-one serves as a building block that can be further modified and functionalized to develop compounds with specific therapeutic properties. The synthesis of these derivatives often involves various chemical reactions, such as substitution, addition, and condensation, to introduce functional groups that enhance their biological activity and selectivity towards target cells or pathways.
The development of naphthyridine-based drugs is an active area of research, as these compounds have demonstrated promising results in preclinical studies. They are being investigated for their potential to treat a wide range of cell proliferative disorders, including various types of cancer. The unique chemical structure of 1H-1,7-Naphthyridin-4-one and its derivatives allows for the fine-tuning of their properties, such as solubility, stability, and bioavailability, which are crucial factors in the design of effective therapeutic agents.

Upstream product

• 161871-65-4 1-(3-nitropyridin-4-yl)ethanone 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 1018812-91-3 8-chloro-1H-1,7-naphthyridin-4-one 
• 952059-56-2 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione 
• 1018812-88-8 4-hydroxy-7-oxido-1,7-naphthyridine 

Downstream Products

• 16287-97-1 4-chloro-[1,7]naphthyridine 
• 58680-40-3 4-bromo-1,7-naphthyridine 
• 1378260-92-4 1,7-naphthyridine-4-carboxylic acid 
• 952059-55-1 2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetic acid 

Relevant academic research and scientific papers

ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.