Technology Process of (-)-S-ethyl (S,E)-4-phenyl-pent-2-enethioate
There total 1 articles about (-)-S-ethyl (S,E)-4-phenyl-pent-2-enethioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane;
at 20 ℃;
for 40h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/jo8010649
- Guidance literature:
-
methylmagnesium bromide;
With
copper(l) iodide; (R)-TolBINAP;
In
diethyl ether; tert-butyl methyl ether;
at -75 ℃;
for 0.0833333h;
Inert atmosphere;
(-)-S-ethyl (S,E)-4-phenyl-pent-2-enethioate;
In
diethyl ether; tert-butyl methyl ether;
at -75 ℃;
for 18.16h;
Inert atmosphere;
With
methanol; ammonium chloride;
In
diethyl ether; tert-butyl methyl ether;
at -75 - 20 ℃;
optical yield given as %ee;
diastereoselective reaction;
DOI:10.1021/jo8010649
- Guidance literature:
-
ethylmagnesium bromide;
With
copper(l) iodide; (R)-TolBINAP;
In
diethyl ether; tert-butyl methyl ether;
at -75 ℃;
for 0.0833333h;
Inert atmosphere;
(-)-S-ethyl (S,E)-4-phenyl-pent-2-enethioate;
In
diethyl ether; tert-butyl methyl ether;
at -75 ℃;
for 18.16h;
Inert atmosphere;
With
methanol; ammonium chloride;
In
diethyl ether; tert-butyl methyl ether;
at -75 - 20 ℃;
optical yield given as %ee;
stereoselective reaction;
DOI:10.1021/jo8010649
