tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

Base Information

Chemical Name:tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate
CAS No.:1338075-40-3
Molecular Formula:C₂₆H₃₅F₂NO₆
Molecular Weight:495.564
Hs Code.:

Synonyms:tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

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Chemical Property of tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

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Technology Process of tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

There total 7 articles about tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338075-39-0
methyl 2-(5-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)pentyloxy)-4,5-difluorobenzoate

: 1338075-40-3
tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

Guidance literature:: methyl 2-(5-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)pentyloxy)-4,5-difluorobenzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 205533-31-9
4,5-difluoro-2-hydroxybenzoic acid

: 1338075-40-3
tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 48 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 1338075-40-3
tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol / 0.5 h / 10 °C

1.2: 1.67 h / -10 - 10 °C

1.3: 0.5 h

2.1: methanol / 10 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; caesium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;