205533-31-9

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-2-hydroxy-benzoic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with anti-inflammatory and anti-bacterial properties.
Used in Agrochemical Industry:
4,5-Difluoro-2-hydroxy-benzoic acid is utilized as a building block in the creation of agrochemicals, where its unique structure and properties can enhance the effectiveness of products designed for agricultural applications.
Used in Organic Chemistry:
4,5-Difluoro-2-hydroxy-benzoic acid serves as a versatile intermediate in organic chemistry, facilitating the synthesis of a wide range of organic compounds for various applications in different industries.

Upstream product

• 80-73-9 1,3-dimethyl-2-imidazolidinone 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 425702-18-7 2-methoxy-4,5-difluorobenzoic acid 
• 749230-48-6 2-chloro-3,4-difluoro-1-(methoxymethoxy)benzene 
• 749230-22-6 1,2-difluoro-4-(methoxymethoxy)benzene 
• 749230-49-7 3-chloro-4,5-difluoro-2-hydroxybenzoic acid 

Downstream Products

• 1015434-11-3 2-acetyloxy-4,5-difluorobenzoic acid 
• 1214375-32-2 methyl 4,5-difluoro-2-hydroxybenzoate 
• 1338075-40-3 tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate 
• 1338075-39-0 methyl 2-(5-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)pentyloxy)-4,5-difluorobenzoate 

Relevant academic research and scientific papers

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation

We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.

A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity

We have developed the practical method for polyfluorosalicylic acids synthesis via nucleophilic ortho-mono-substitution of fluorine atom with magnesium methoxide. We have managed to increase the yield of targeted polyfluorosalicylic acids from good to quantitative. We have studied the tuberculostatic activity of polyfluorosalicylic acids. It has been found that minimum inhibitory concentration (MIC) of compounds is from 0.7 to 6.5 μg/mL depending on the structure.

PLATELET ADP RECEPTOR INHIBITORS

Compounds are provided which are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives

Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substi

BICYCLIC TRIAZOLONE DERIVATIVES AND HERBICIDES CONTAINING THE SAME

The present invention provides a bicyclic triazolone derivative represented by the formula:J-Ar [wherein, J is and Ar is ], which has excellent selective weeding activity and weed killer containing the said bicyclic triazolone derivative.

4-fluorosalicyclic acid derivative and process for production thereof

PCT No. PCT/JP97/03761 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17620 PCT Pub. Date Apr. 30, 1998The present invention provides a 4-fluorosalicylic acid derivative represented by the following ge