1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Base Information

Chemical Name:1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide
CAS No.:86543-07-9
Molecular Formula:C₂₀H₂₈N₄O₃S
Molecular Weight:404.533
Hs Code.:

Synonyms:1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Suppliers and Price of 1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

There total 2 articles about 1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 86542-86-1
piperidine-4-carboxylic acid tert-butylamide

: 43091-89-0
2-isothiocyanato-4,5-dimethoxybenzonitrile

: 86543-07-9
1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Guidance literature:: In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/jm00364a014

Reference yield:

: benzyl 4-(tert-butylcarbamoyl)piperidine-1-carboxylate

: 86543-07-9
1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / 1 N aq. HCl, H₂ / Pd/C / methanol / 760 Torr / Ambient temperature

2: 89 percent / dimethylformamide / 0 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014