1-(2-Bromophenyl)-2-nitrobenzene

Base Information

• Chemical Name: 1-(2-Bromophenyl)-2-nitrobenzene
• CAS No.: 17613-47-7
• Molecular Formula: C12H8BrNO2
• Molecular Weight: 278.105
• DSSTox Substance ID: DTXSID50355330
• Wikidata: Q82134150
• Mol file: 17613-47-7.mol

Synonyms:17613-47-7;1-(2-bromophenyl)-2-nitrobenzene;2'-Bromo-2-nitro-biphenyl;2-BROMO-2'-NITROBIPHENYL;2-bromo-2'-nitro-1,1'-biphenyl;2'-Bromo-2-nitrobiphenyl;Cambridge id 5111391;CBDivE_002260;SCHEMBL7695295;DTXSID50355330;1-(2-bromophenyl)-2-nitro-benzene;AKOS015909458;A812150

Chemical Property of 1-(2-Bromophenyl)-2-nitrobenzene

Chemical Property:

• Boiling Point: 359.5 °C at 760 mmHg
• Flash Point: 171.2 °C
• PSA: 45.82000
• Density: 1.521 g/cm³
• LogP: 4.54750
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 276.97384
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=CC=C2Br)[N+](=O)[O-]

Technology Process of 1-(2-Bromophenyl)-2-nitrobenzene

There total 8 articles about 1-(2-Bromophenyl)-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-nitrophenyl bromide (577-19-5) + (2-bromophenyl)boronic acid (244205-40-1) → 2-bromo-2′-nitro-1,1′-biphenyl (17613-47-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acschemneuro.8b00291

Reference yield: 92.0%

o-nitroiodobenzene (609-73-4) + (2-bromophenyl)boronic acid (244205-40-1) → 2-bromo-2′-nitro-1,1′-biphenyl (17613-47-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; for 24h; Inert atmosphere; Reflux;

Reference yield: 81.2%

1-Bromo-2-iodobenzene (583-55-1) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene (190788-59-1) → 2-bromo-2′-nitro-1,1′-biphenyl (17613-47-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; toluene; for 12h; Reflux;

upstream raw materials:

1-Bromo-2-iodobenzene

o-nitroiodobenzene

2-amino-2'-nitrobiphenyl

1-nitro-2-(2-nitrophenyl)benzene

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3,3-dimethyl-1-((R)-2-(9-methyl-9H-carbazol-4-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)thiourea

4-bromo-9H-carbazole

4-bromo-9-diphenyl-9H-carbazole