4-BroMo-9H-carbazole

Base Information

• Chemical Name: 4-BroMo-9H-carbazole
• CAS No.: 3652-89-9
• Molecular Formula: C12H8BrN
• Molecular Weight: 246.106
• Hs Code.: 2933990090
• Mol file: 3652-89-9.mol

Synonyms:4-Brom-butyroylbromid;4-bromo-butyryl bromide;4-Brom-carbazol;4-Brom-butyrylbromid;4-bromo-carbazole;Butanoyl bromide,4-bromo;

Chemical Property of 4-BroMo-9H-carbazole

Chemical Property:

• Melting Point: 104-105℃
• Boiling Point: 409.2±18.0 °C(Predicted)
• PKA: 16.04±0.30(Predicted)
• PSA: 15.79000
• Density: 1.617±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 4.08360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-BROMO-9H-CARBAZOLE is a useful research chemical.

Technology Process of 4-BroMo-9H-carbazole

There total 28 articles about 4-BroMo-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

C12H9Br2N → 4-bromo-9H-carbazole (3652-89-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; at 150 ℃; for 3h; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield: 92.5%

1,3-dibromobenzene (108-36-1) + 2-bromoaniline (615-36-1) → 4-bromo-9H-carbazole (3652-89-9)

Guidance literature:

With palladium diacetate; sodium t-butanolate; XPhos; at 130 ℃; for 24h; Temperature; Inert atmosphere;

Reference yield: 87.0%

2-bromo-2′-nitro-1,1′-biphenyl (17613-47-7) → 4-bromo-9H-carbazole (3652-89-9)

Guidance literature:

With triphenylphosphine; In 1,2-dichloro-benzene; for 12h; Reflux;

DOI:10.1016/j.orgel.2012.10.011

upstream raw materials:

5-bromo-1,2,3,4-tetrahydrocarbazole

cyclohexanone

3-bromophenylhydrazine

o-nitroiodobenzene

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3,3-dimethyl-1-((R)-2-(9-methyl-9H-carbazol-4-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)thiourea

4-bromo-9-diphenyl-9H-carbazole

(9-phenyl-9H-carbazol-4-yl)boronic acid

Refernces

• 1、 -. "Preparation method of 4-bromocarbazole". Paragraph 0041-0057; 0060-0063. . Retrieved 2020/12/08.
• 2、 Elmabruk, Asma,Das, Banibrata,Yedlapudi, Deepthi,Xu, Liping,Antonio, Tamara,Reith, Maarten E. A.,Dutta, Aloke K.. "Design, Synthesis, and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson's Disease". . p. 396 - 411. Retrieved 2019/01/24.