5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

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Chemical Name:5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile
CAS No.:1403680-25-0
Molecular Formula:C₁₆H₉ClF₃N₅
Molecular Weight:363.729
Hs Code.:

Synonyms:5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

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Chemical Property of 5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

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Technology Process of 5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

There total 5 articles about 5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 593-85-1,90332-86-8,3425-08-9
guanidine carbonate

: 1403680-24-9
2-[2-chloro-5-(trifluoromethyl)phenyl]-5-((E)-3-dimethylamino-acryloyl)-1H-pyrrole-3-carbonitrile

: 1403680-25-0
5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 2h;

Reference yield:

: 1403679-87-7
3-[2-chloro-5-(trifluoromethyl)phenyl]-3-[(2,2-diethoxyethyl)amino]prop-2-enenitrile

: 1403680-25-0
5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 0.5 h / 5 - 20 °C

2: zinc / toluene / 3 h / 80 °C / Inert atmosphere

3: toluene / 2 h / 80 °C

4: N,N-dimethyl-formamide / 2 h / 110 °C

With trifluoroacetic acid; zinc; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 1403679-88-8
2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

: 1403680-25-0
5-(2-amino-pyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: zinc / toluene / 3 h / 80 °C / Inert atmosphere

2: toluene / 2 h / 80 °C

3: N,N-dimethyl-formamide / 2 h / 110 °C

With zinc; In N,N-dimethyl-formamide; toluene;