(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

Base Information

Chemical Name:(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide
CAS No.:1414884-63-1
Molecular Formula:C₂₆H₂₇ClFN₅O₂
Molecular Weight:495.984
Hs Code.:

Synonyms:(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

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Chemical Property of (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

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Technology Process of (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

There total 5 articles about (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.9%

: 1245555-80-9
(E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)but-2-enamide

: 1414885-15-6
2-azaspiro-[3.4]-octane hydrochloride

: 1414884-63-1
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 13.9%

: 1414885-15-6
2-azaspiro-[3.4]-octane hydrochloride

: 1414884-63-1
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 179552-74-0
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin- 4-amine

: 1414884-63-1
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl]-4-[2-azaspiro[ 3.4]octan-2-yl]-2-butenamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / tetrahydrofuran / 24 h / 20 °C

2: triethylamine / tetrahydrofuran / 1 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;