5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester
• CAS No.: 265657-43-0
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.281

Synonyms:5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester

Chemical Property of 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester

There total 5 articles about 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-methylazidobenzene (2101-86-2) + ethyl acetoacetate (141-97-9) → 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester (265657-43-0)

Guidance literature:

With 2-hydroxy-N,N,N-trimethylethanaminium 2,2,2-trichloroacetate; at 50 ℃; for 2h;

DOI:10.1039/c8gc03119c

Reference yield: 81.0%

ethanol (64-17-5) + 5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxylic acid (210159-05-0) → 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester (265657-43-0)

Guidance literature:

With sulfuric acid; for 10h; Heating;

DOI:10.1002/jccs.200000044 DOI:10.1002/jccs.200000072

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-carboxylic acid ethyl ester (265657-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride / water

2: Alkaline conditions

With hydrogenchloride; sodium nitrite; In water;

DOI:10.1016/j.molstruc.2021.131146

upstream raw materials:

p-methylazidobenzene

ethyl acetoacetate

ethanol

5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxylic acid

Downstream raw materials:

5-methyl-1-(4-methylphenyl)-1,2,3-triazole-4-carbonylhydrazine

C₂₃H₂₁N₃O

C₂₃H₁₉Cl₂N₃O

bis(3-chlorophenyl)-[5-methyl-1-(4-methylphenyl)-1,2,3-triazol-4-yl]-methanol

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