5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine

Base Information

Chemical Name:5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine
CAS No.:950845-92-8
Molecular Formula:C₁₁H₁₀BrN₃O
Molecular Weight:280.124
Hs Code.:
DSSTox Substance ID:DTXSID20696944
Wikidata:Q82626730

Synonyms:5-BROMO-N-(4-METHOXYPHENYL)PYRAZIN-2-AMINE;950845-92-8;SCHEMBL646982;DTXSID20696944;RRCDAYXAURXRIT-UHFFFAOYSA-N;(5-bromo-pyrazin-2-yl)-(4-methoxy-phenyl)-amine;A845172

Suppliers and Price of 5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:279.00072
Heavy Atom Count:16
Complexity:209

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NC2=CN=C(C=N2)Br

Technology Process of 5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine

There total 1 articles about 5-Bromo-N-(4-methoxyphenyl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 5720-07-0
4-methoxyphenylboronic acid

: 950845-92-8
(5-bromo-pyrazin-2-yl)-(4-methoxy-phenyl)-amine

Guidance literature:: With dmap; copper diacetate; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 950845-92-8
(5-bromo-pyrazin-2-yl)-(4-methoxy-phenyl)-amine

: [5-(5-methoxy-2-trifluoromethyl-benzoimidazol-1-yl)-pyrazin-2-yl]-(2-methyl-benzyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid; acetic acid / 10 - 40 °C

2.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C

3.1: 1 h / 80 °C

3.2: pH 9 - 10

3.3: 3 h / 100 °C

4.1: L-proline; copper(l) iodide / dimethyl sulfoxide / 1 h / 50 °C

With copper(l) iodide; nitric acid; acetic acid; L-proline; zinc; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 950845-92-8
(5-bromo-pyrazin-2-yl)-(4-methoxy-phenyl)-amine

: 950846-00-1
(E)-2-bromo-N-[1-(2-bromo-benzoyl)-5-(5-methoxy-2-trifluoromethyl-benzoimidazol-1-yl)-1H-pyrazin-2-ylidene]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; acetic acid / 10 - 40 °C

2.1: zinc; acetic acid / dichloromethane; ethanol / 0.5 h / 20 °C

3.1: 1 h / 80 °C

3.2: pH 9 - 10

3.3: 3 h / 100 °C

4.1: copper(I) oxide; ammonia / ethylene glycol / Sealed tube

5.1: dichloromethane / 8 h / 20 °C

With copper(I) oxide; ammonia; nitric acid; acetic acid; zinc; In ethanol; dichloromethane; ethylene glycol;