5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Base Information

Chemical Name:5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one
CAS No.:1448868-11-8
Molecular Formula:C₂₇H₂₅Cl₂FN₆O₂
Molecular Weight:555.439
Hs Code.:

5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Synonyms:5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Chemical Property of 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Technology Process of 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

There total 3 articles about 5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448870-56-1
5-(3-chloro-2-fluoro-phenyl)-2-(2-chloro-5-methoxy-pyrimidin-4-yl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

: 124-40-3
dimethyl amine

: 1448868-11-8
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: In tetrahydrofuran; at 70 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1448869-77-9
2-bromo-5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

: 1448868-11-8
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

1.2: 70 - 80 °C

2.1: tetrahydrofuran / 24 h / 70 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride; In tetrahydrofuran;

Reference yield:

: 22536-65-8
2-chloro-5-methoxy-pyrimidine

: 1448868-11-8
5-(3-chloro-2-fluoro-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-5-methoxy-pyrimidin-4-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

1.2: 70 - 80 °C

2.1: tetrahydrofuran / 24 h / 70 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride; In tetrahydrofuran;